¹⁹F NMR as a tool in chemical biology

• Diana Gimenez,
• Aoife Phelan,
• Cormac D. Murphy and
• Steven L. Cobb

Beilstein J. Org. Chem. 2021, 17, 293–318, doi:10.3762/bjoc.17.28

• significantly no new 19F resonances were produced during the time course of aggregation. This suggests that, unlike what is observed in the case of amyloidogenic Aβ-peptide, no soluble intermediates accumulate in the aggregation pathway of IAPP. Conformational polymorphism is also particularly important for the

Self-assembled monolayers of shape-persistent macrocycles on graphite: interior design and conformational polymorphism

• Joscha Vollmeyer,
• Friederike Eberhagen,
• Sigurd Höger and
• Stefan-S. Jester

Beilstein J. Org. Chem. 2014, 10, 2774–2782, doi:10.3762/bjoc.10.294

• -dimensional (2D) crystalline monolayer patterns are obtained by in situ scanning tunneling microscopy. A concentration-dependent conformational polymorphism is found, and open and more dense packing motifs are observed. For all three compounds alike lattice parameters are found, therefore the intermolecular

• macrocycle distances are mainly determined by their size and symmetry. This is an excellent example that the graphite acts as a template for the macrocycle organization independent from their specific interior. Keywords: conformational polymorphism; self-assembled monolayers; shape-persistent macrocycles

• 2D superstructures are not predictable [17] or show a conformational polymorphism [18], also as an effect of varying compound concentrations in the supernatant solution [19][20]. A recent approach investigating macrocycles of triangular, quadratic, pentagonal, and hexagonal shapes that carry alkoxy